The study aimed to identify the role of knowledge management requirements in achieving strategic success and competitive advantage by applying them to a sample of Palestinian universities. The study adopted the descriptive approach, case study method, and historical method, with the questionnaire serving as the primary tool for data collection. The study population included all employees in supervisory positions at Palestinian universities in the southern governorates, totaling 425 individuals. A sample of 202 employees was selected, and 250 questionnaires were distributed, of which 239 were retrieved, representing the study sample and Key findings of the study include: The level of knowledge management application in Palestinian universities in the southern governorates was rated as “high.” Participants expressed strong agreement on the strategic success dimension in Palestinian universities, also rated as “high.” The competitive advantage in Palestinian universities was similarly rated as “high.” The results indicated a statistically significant impact of knowledge management on strategic success in Palestinian universities. Additionally, there was a significant impact of knowledge diagnosis on strategic success and a statistically significant effect of knowledge management on competitive advantage in these universities. And The study offered several recommendations, most notably: Universities should leverage internal expertise and external resources to assess the adequacy of their intellectual capital, Universities must identify gaps in knowledge resources and involve employees in decision-making processes to enhance their responsiveness. Providing facilities and technical tools to support self-learning and professional development for staff is essential. University management should prioritize attracting external talents to contribute to the development of knowledge accumulation methods and support research and development activities to enhance institutional performance. Academic programs should be designed with high efficiency, and universities should strive to meet societal needs while focusing on knowledge dissemination through seminars and workshops conducted by specialized experts for university staff................. Keywords:........... Knowledge Management, Competitive Advantage, Palestinian Universities.