This paper studied the effects of a natural pigment (anthocynan-rich pigment) which was extracted on the physiological and biochemical condition of female Wistar rats. The three groups conducted were exposed to either 25 or 12.5 mg/kg daily dose orally administered within three weeks respectively. Indicators of the weight of the body, the indicators of liver functional and kidney functional indicators and the structure of the tissue were monitored. The rodent group administered the lower dose reported a significant increase in weight, as well as lack of biochemical imbalances. Conversely, sinusoidal dilatation and vascular congestion of the liver tissue were observed in the higher dose group albeit the values of liver and kidney functions were within the acceptable limits. These findings indicate the safety of the extract at low dose, but warn of possible hepatic effects with greater exposure, indicating a critical control of dose before pre- or post-food or pre-medical intake. ........................... Keywords:.................... Natural pigments, Anthocyanins, Pistacia lentiscus, Toxicity, Histopathology