This study focuses on the artificial lift selection and optimization for Well E-25 in the (103-E). Intesar Field, Sirt Basin, Libya. Reservoir characteristics and production history analyzed to determine the most suitable artificial lift method. Gas lifting and electric submersible pumps (ESPs) evaluated. Production has been simulated in PROSPER software for different scenarios and methods. The results indicate that gas lifting offers simplicity and can be optimize through completion design, while ESPs have a limited lifetime, increasing project costs. The production analysis of Well E-25 demonstrates the superiority of the ESP solution, which can also enhance production and recovery factors for the field. However, gas lifting can be advantageous with efficient water injection management, resulting in increased fluid production and maintaining pressure and water cut. Gas lifting may be a cost-effective choice when multiple wells use this method.E25 well's performance curve graph shows that the operational point's liquid flow rate is 999.5 stb/d. The gas lift performance curve also shows that liquid flow rates are 875.5 stb/d. Keywords: Artificial lift, gas lifting, electric submersible pump, production analysis, PROSPER software, Intesar Field, Sirt Basin, Libya