Corona virus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which has resulted in a devastating pandemic since December 2019. It is unclear how weather conditions influence transmission. So that was the goal of this study. Reevaluate the impact of weather on COVID-19, focusing on local climate effects. We analyzed daily COVID-19 case data and weather factors such as temperature, rain amount This work will cover a diurnal temperature range from March 3 to December 31, 2021 in Telmetha, a coastal rural area in northeastern Libya. This study was conducted over ten months under various climatic conditions. 167 Nasal swab samples were tested for COVID-19 from at Telmetha rural hospital were collected under aseptic conditions. The COVID-19 infections in the samples were found using the Panbio™ COVID-19 Ag Rapid Test Device. The findings revealed that 36.5% of the samples were infected with COVD-19. The study found that more than 65.6% of COVID19 infections were in male samples. As rainfall increased, the number of infections slightly increased as well, and temperature was a limiting factor for COVID19 in Telmetha Rural. The infections were peaked during November and December and October and lowered in spring and autumn . These findings are agreed with different results from temperate zones. while they differed with others from the tropics........................... Keywords: ...........SARS-CoV-2, COVID-19, Environmental factors, transmission.