Growing concerns about climate change due to global warming, the extensive use of refrigerants, and their impact on the ozone layer necessitate the search for environmentally friendly alternative refrigerants that operate efficiently in energy-optimized systems. This study aims to compare the thermodynamic properties of several potential alternative refrigerants to the conventional R22 across various flow rates, while considering environmental impact and safety criteria. The analysis was conducted at flow rates of 1.0, 1.25, 1.50, 1.75, and 2.0 kg/min for the proposed alternatives—R410A, R407A, R407C, R417A, and R438A. Their thermodynamic properties were evaluated and compared. In addition, predictive equations were developed for key thermodynamic parameters as functions of flow rate. The results indicate that R407C exhibits the closest thermodynamic behavior to R22, including similar trends in the predictive equations. These equations can be used to estimate condensation heat, vaporization heat, work input, and theoretical displacement within the studied operating range. The study recommends further investigations involving the same refrigerants using a vapor-compression refrigeration cycle equipped with a heat exchanger or incorporating two consecutive vapor-compression refrigeration cycles............... Keywords:........... Refrigerants, Thermodynamics, Evaporation, Condensation, Predictive Modeling, Work, Energy Efficiency, Flow Rate.