Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that functions similarly to other NSAIDs but also inhibits the normal activity of platelets. It is the most widely produced and sold medication worldwide. This study aimed to produce aspirin in an environmentally friendly way and compare it to the traditional method. Aspirin is typically manufactured using acetic anhydride and salicylic acid. The process involves reacting salicylic acid with acetic anhydride in the presence of a catalyst (such as phosphoric acid or sulfuric acid) or without a catalyst, following environmentally friendly and traditional methods. Aspirin production is carried out through a series of carefully controlled steps. Conventional heating requires 25-30 minutes at 60 °C to synthesize aspirin, while microwave techniques achieve comparable or higher yields with shorter reaction times (5-8 minutes at 175 W). The yield of aspirin using microwaves with a catalyst was 92%, whereas without a catalyst, it was 82%, compared to 76% with the conventional method. From these results, we conclude that microwave synthesis reduces time consumption and produces a higher purity, better-quality product. We recommend conducting more extensive studies using the microwave method on aspirin and other compounds............... Keywords:............aspirin, synthesis, salicylic acid, acetic anhydride, acetylsalicylic acid