Pulmonary fibrosis is a chronic disease marked by excessive fibroblast proliferation and extracellular matrix accumulation. Tapak Liman, a medicinal plant rich in flavonoids and phenolic acids, has shown promise in reducing oxidative stress and inflammation. Objective; To evaluate the efficacy of Elephantopus scaber ethanol extract (ESEE) treatment in preventing the development of fibrosis in a murine model of pulmonary fibrosis induced by bleomycin. Method; A total of fifty-six healthy male BALB/c mice were randomly assigned to seven experimental groups, with eight mice per group. The groups; healthy controls (NC), vehicle controls (VC), negative controls (C-), positive controls (C+), and treatment groups receiving ESEE at different doses: D1 (0.0504 mg/kg), D2 (0.1008 mg/kg), and D3 (0.2016 mg/kg). Mice were administered dexamethasone or ESEE orally, with bleomycin given intraperitoneally for 14 days. On days 7 and 14, spleens were harvested, Interleukin-6 (IL-6) and Tumor Necrosis Factor Alpha (TNF-α) production were analysed via flow cytometry. Results: Increase of Tumor Necrosis Factor Alpha was found in the macrophage of pulmonary fibrosis mice model from day 7 to 14. The production of Interleukin-6 was reduced in the fibrosis group at day 7 and continued to increase at day 14. Interestingly, ESEE treatment for 14 days could effectively reduce Tumor Necrosis Factor Alpha production, and could maintain a stable production of IL-6 at each time point. ESEE at 0.1008 mg/kg BW (D2) was the most effective dose in reducing pro- fibrotic cytokine. Conclusion; this study highlights the therapeutic potential of Tapak Liman in the treatment of pulmonary fibrosis, particularly by reducing inflammation and oxidative stress. Its bioactive compounds (flavonoids and terpenoids), provide promising for the development of natural therapies for chronic lung diseases................. Keywords:.............. Elephantopus scaber, Bleomycin, Pulmonary Fibrosis, Tumor Necrosis Factor Alpha, Interleukin-6.