Background: Poor ovarian response (POR) affects 9–24% of women undergoing ovarian stimulation. The optimal Follicle-Stimulating Hormone )FSH( dose for improving ovarian response in POR patients with low ovarian reserve remains controversial. Objective: To compare the effect of high dose (300–450 IU/day) versus low dose (150–225 IU/day) FSH on ovarian response improvement and to identify predictors of normal response. Methods: A retrospective study was conducted on 100 POR women (mean age 37.5 ± 1.7 years; 50 low dose, 50 high dose) at the Al Bayda – Al Jabal Al Akhdar National Educational Center for Diagnosis and Treatment of Infertility. All patients had documented poor response before treatment. After FSH stimulation, response was classified as Poor (follicles < 3 AND Estradiol (E₂) < 500 pg/mL) or Normal (follicles ≥ 3 OR E₂ ≥ 500 pg/mL). Chi-square, independent t-tests, Pearson correlation, and logistic regression were used. Results: The improvement rate was 26% (13/50) in the low dose group and 38% (19/50) in the high dose group, with no significant difference (χ² = 1.654, df = 1, p = 0.198). No significant differences were observed in follicle count (2.04 ± 0.70 vs. 2.26 ± 0.92, p = 0.182) or peak E₂ (445.8 ± 104.7 vs. 467.4 ± 140.9 pg/mL, p = 0.386). Anti-Müllerian Hormone (AMH) was strongly correlated with follicle count (r = 0.772, p < 0.001). Conclusion: High dose FSH did not significantly improve ovarian response compared to low dose FSH in poor responders with low ovarian reserve. A low dose protocol (150–225 IU/day) is a reasonable first-line strategy................ Keywords:...............Poor ovarian response, FSH dose, ovarian reserve, AMH, retrospective study, improvement rate.