This study investigated the proximate chemical composition and qualitative bioactive profile of dry pomegranate peels and pressed seed residues (obtained after juice extraction), while evaluating the antibacterial activity of both their fresh and dry aqueous extracts. Methodology involved applying standard and modified AOAC methods on the dry plant parts to determine basic components (moisture, ash, fiber, fat, protein, and reducing sugars). Aqueous extraction using distilled water was performed on the dry materials for chemical screening of nine bioactive groups, and on both fresh and dry forms for the antibacterial assay against Escherichia coli, Klebsiella, and Streptococcus species. Results revealed that dry peels contained 8.00 % ± 0.01 moisture, 4.9 % ± 0.07 ash, 21.00 % ± 0.77 fiber, 5.00 % ± 0.97 fat 6.14 %, ± 0.09 protein, and 7.00 % ± 0.89 reducing sugars, while dry pressed seed residues contained 14.50 % ± 0.75 moisture, 3.60 % ± 0.25 ash, 37.00 % ± 1.02 fiber, 10.00 % ± 0.98 fat, 8.76 % ± 0.05 protein, and 20.00 % ± 0.35 reducing sugars. Qualitative screening of the dry parts confirmed the presence of nine bioactive groups; based on a semi-quantitative assessment of reaction color intensity, phenols were highest (+++) in pressed seed residues, followed by peels (++). Notably, the antibacterial assay demonstrated potent growth inhibition against most of the tested pathogenic bacterial strains across the evaluated extracts. Overall, these positive findings strongly support utilizing dry pomegranate residues as potent and sustainable natural sources for functional food and pharmaceutical industries, particularly for their application as antibacterial agents................ Keywords:.................. Pomegranate residues, pomegranate peels, pressed seed residues, phenols, Aqueous extract, proximate composition, antimicrobial, Klebsiella.