Information security is necessary to protect and secure the resources used, where works on its confidentiality and integrity, in the absence of information security, deficiency or non-utilization of it, this leads to the existence of loopholes such as unauthorized access or use for data. For this reason, information security is one of the necessary pillars in protecting individuals and institutions from the resulting damage. To ensure information security, there are several accurate, appropriate and reliable methods used not to disclose stored data and information that affect the functioning of research centers. This study aimed to assess the reality of information security in the research centers of the Research, Natural Sciences and Technology Authority. By identifying the availability of procedures and control methods for information security and how to develop information security management in these research centers. Where a questionnaire was used as a means to collect information and to test the study's hypotheses, by using SPSS (Statistical Package for Social Science), To reach results for developing the information security policy in these centers and to take all necessary measures to spread the culture of information security at the various administrative and technical levels in the centers